IEEE/ACM Transactions on Computational Biology and Bioinformatics

IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB) is a bimonthly journal that publishes archival research results related to the algorithmic, mathematical, statistical, and computational methods that are central in bioinformatics and computational biology. Read the full scope of TCBB

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From the September/October 2017 Issue

Exploring Consensus RNA Substructural Patterns Using Subgraph Mining

By Qingfeng Chen, Chaowang Lan, Baoshan Chen, Lusheng Wang, Jinyan Li, and Chengqi Zhang

Featured article thumbnail imageFrequently recurring RNA structural motifs play important roles in RNA folding process and interaction with other molecules. Traditional index-based and shape-based schemas are useful in modeling RNA secondary structures but ignore the structural discrepancy of individual RNA family member. Further, the in-depth analysis of underlying substructure pattern is insufficient due to varied and unnormalized substructure data. This prevents us from understanding RNAs functions and their inherent synergistic regulation networks. This article thus proposes a novel labeled graph-based algorithm RnaGraph to uncover frequently RNA substructure patterns. Attribute data and graph data are combined to characterize diverse substructures and their correlations, respectively. Further, a top-k graph pattern mining algorithm is developed to extract interesting substructure motifs by integrating frequency and similarity. The experimental results show that our methods assist in not only modelling complex RNA secondary structures but also identifying hidden but interesting RNA substructure patterns.

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  • We are pleased to announce that Aidong Zhang, the SUNY Distinguished Professor in the Department of Computer Science and Engineering at the University at Buffalo, The State University of New York, has been named the new Editor-in-Chief of the IEEE/ACM Transactions on Computational Biology and Bioinformatics starting in 2017.

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TCBB is a joint publication of the IEEE Computer Society, Association for Computing Machinery, IEEE Computational Intelligence Society, and the IEEE Engineering in Medicine and Biology Society.

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