IEEE/ACM Transactions on Computational Biology and Bioinformatics

IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB) is a bimonthly journal that publishes archival research results related to the algorithmic, mathematical, statistical, and computational methods that are central in bioinformatics and computational biology. Read the full scope of TCBB


Expand your horizons with Colloquium, a monthly survey of abstracts from all CS transactions! Replaces OnlinePlus in January 2017.


From the July/August 2017 Issue

Impact of Synaptic Localization and Subunit Composition of Ionotropic Glutamate Receptors on Synaptic Function: Modeling and Simulation Studies

By Anne Florence Keller, Nicolas Ambert, Arnaud Legendre, Mathieu Bedez, Jean-Marie Bouteiller, Serge Bischoff, Michel Baudry, and Saliha Moussaoui

Featured article thumbnail imageIonotropic NMDA and AMPA glutamate receptors (iGluRs) play important roles in synaptic function under physiological and pathological conditions. iGluRs sub-synaptic localization and subunit composition are dynamically regulated by activity-dependent insertion and internalization. However, understanding the impact on synaptic transmission of changes in composition and localization of iGluRs is difficult to address experimentally. To address this question, we developed a detailed computational model of glutamatergic synapses, including spine and dendritic compartments, elementary models of subtypes of NMDA and AMPA receptors, glial glutamate transporters, intracellular calcium, and a calcium-dependent signaling cascade underlying the development of long-term potentiation (LTP). These synapses were distributed on a neuron model and numerical simulations were performed to assess the impact of changes in composition and localization (synaptic versus extrasynaptic) of iGluRs on synaptic transmission and plasticity following various patterns of presynaptic stimulation. In addition, the effects of various pharmacological compounds targeting NMDARs or AMPARs were determined. Our results showed that changes in NMDAR localization have a greater impact on synaptic plasticity than changes in AMPARs. Moreover, the results suggest that modulators of AMPA and NMDA receptors have differential effects on restoring synaptic plasticity under different experimental situations mimicking various human diseases.

download PDF View the PDF of this article      csdl View this issue in the digital library


Editorials and Announcements

Announcements

  • We are pleased to announce that Aidong Zhang, the SUNY Distinguished Professor in the Department of Computer Science and Engineering at the University at Buffalo, The State University of New York, has been named the new Editor-in-Chief of the IEEE/ACM Transactions on Computational Biology and Bioinformatics starting in 2017.

  • Get Your Journals as eBooks for Free

Editorials


Guest Editorials


Call for Papers


Reviewers List


Author Index


Access All Recently Published TCBB Articles

RSS Subscribe to the RSS feed of latest TCBB content added to the digital library

Mail Sign up for the Transactions Connection newsletter.


TCBB is a joint publication of the IEEE Computer Society, Association for Computing Machinery, IEEE Computational Intelligence Society, and the IEEE Engineering in Medicine and Biology Society.

IEEE Computer Society    ACM    Engineering in Medicine and Biology Society

Published in cooperation with: IEEE Control Systems Society


MEDLINE      PubMed

Indexed in MEDLINE®/PubMed® & ISI