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We study a new data mining problem concerning the discovery of frequent agreement subtrees (FASTs) from a set of phylogenetic trees. A phylogenetic tree, or phylogeny, is an unordered tree in which the order among siblings is unimportant. Furthermore, each leaf in the tree has a label representing a taxon (species or organism) name whereas internal nodes are unlabeled. The tree may have a root, representing the common ancestor of all species in the tree, or may be unrooted. An unrooted phylogeny arises due to the lack of sufficient evidence to infer a common ancestor of the taxa in the tree. The FAST problem addressed here is a natural extension of the MAST (maximum agreement subtree) problem widely studied in the computational phylogenetics community. The paper establishes a framework for tackling the FAST problem for both rooted and unrooted phylogenetic trees using data mining techniques. We first develop a novel canonical form for rooted trees together with a phylogeny-aware tree expansion scheme for generating candidate subtrees level by level. Then we present an efficient heuristic to find all frequent agreement subtrees in a given set of rooted trees, through an Apriori-like approach. We show the correctness and completeness of the proposed method. Finally we discuss extensions of the techniques to unrooted trees. Experimental results demonstrate that the proposed methods work well, capable of finding interesting patterns in both synthetic data and real phylogenetic trees.
Data mining, Bioinformatics (genome or protein) databases
Jason T.L. Wang, Sen Zhang, "Discovering Frequent Agreement Subtrees from Phylogenetic Data", IEEE Transactions on Knowledge & Data Engineering, vol. 20, no. , pp. 68-82, January 2008, doi:10.1109/TKDE.2007.190676
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