Issue No. 03 - May-June (2016 vol. 13)
Sajad Mirzaei , , Department of Computer Science and Engineering, Storrs, CT
Yufeng Wu , , Department of Computer Science and Engineering, Storrs, CT
Hybridization networks represent plausible evolutionary histories of species that are affected by reticulate evolutionary processes. An established computational problem on hybridization networks is constructing the most parsimonious hybridization network such that each of the given phylogenetic trees (called gene trees) is “displayed” in the network. There have been several previous approaches, including an exact method and several heuristics, for this NP-hard problem. However, the exact method is only applicable to a limited range of data, and heuristic methods can be less accurate and also slow sometimes. In this paper, we develop a new algorithm for constructing near parsimonious networks for multiple binary gene trees. This method is more efficient for large numbers of gene trees than previous heuristics. This new method also produces more parsimonious results on many simulated datasets as well as a real biological dataset than a previous method. We also show that our method produces topologically more accurate networks for many datasets.
Vegetation, 5G mobile communication, Phylogeny, IEEE transactions, Computational biology, Bioinformatics
S. Mirzaei and Y. Wu, "Fast Construction of Near Parsimonious Hybridization Networks for Multiple Phylogenetic Trees," in IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 13, no. 3, pp. 565-570, 2016.