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Issue No. 01 - Jan.-Feb. (2014 vol. 11)
ISSN: 1545-5963
pp: 7-16
Liang Zhao , Dept. of Pediatrics, Baylor Coll. of Med., Houston, TX, USA
Steven C. H. Hoi , Sch. of Comput. Eng., Nanyang Technol. Univ., Singapore, Singapore
Zhenhua Li , Sch. of Comput. Eng., Nanyang Technol. Univ., Singapore, Singapore
Limsoon Wong , Sch. of Comput., Nat. Univ. of Singapore, Singapore, Singapore
Hung Nguyen , Center for Health Technol., Univ. of Technol. Sydney, Sydney, NSW, Australia
Jinyan Li , Adv. Analytics Inst., Univ. of Technol. Sydney, Sydney, NSW, Australia
Coupling graphs are newly introduced in this paper to meet many application needs particularly in the field of bioinformatics. A coupling graph is a two-layer graph complex, in which each node from one layer of the graph complex has at least one connection with the nodes in the other layer, and vice versa. The coupling graph model is sufficiently powerful to capture strong and inherent associations between subgraph pairs in complicated applications. The focus of this paper is on mining algorithms of frequent coupling subgraphs and bioinformatics application. Although existing frequent subgraph mining algorithms are competent to identify frequent subgraphs from a graph database, they perform poorly on frequent coupling subgraph mining because they generate many irrelevant subgraphs. We propose a novel graph transformation technique to transform a coupling graph into a generic graph. Based on the transformed coupling graphs, existing graph mining methods are then utilized to discover frequent coupling subgraphs. We prove that the transformation is precise and complete and that the restoration is reversible. Experiments carried out on a database containing 10,511 coupling graphs show that our proposed algorithm reduces the mining time very much in comparison with the existing subgraph mining algorithms. Moreover, we demonstrate the usefulness of frequent coupling subgraphs by applying our algorithm to make accurate predictions of epitopes in antibody-antigen binding.
Couplings, Bioinformatics, Databases, Prediction algorithms, Proteins, Fuel processing industries, Computational biology

Liang Zhao, S. C. Hoi, Zhenhua Li, Limsoon Wong, Hung Nguyen and Jinyan Li, "Coupling Graphs, Efficient Algorithms and B-Cell Epitope Prediction," in IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 11, no. 1, pp. 7-16, 2014.
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