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Issue No. 01 - Jan.-Feb. (2013 vol. 10)
ISSN: 1545-5963
pp: 87-97
Jagath C. Rajapakse , Sch. of Comput. Eng., Nanyang Technol. Univ., Singapore, Singapore
Piyushkumar A. Mundra , Bioinf. Res. Center, Nanyang Technol. Univ., Singapore, Singapore
ABSTRACT
Filter methods are often used for selection of genes in multiclass sample classification by using microarray data. Such techniques usually tend to bias toward a few classes that are easily distinguishable from other classes due to imbalances of strong features and sample sizes of different classes. It could therefore lead to selection of redundant genes while missing the relevant genes, leading to poor classification of tissue samples. In this manuscript, we propose to decompose multiclass ranking statistics into class-specific statistics and then use Pareto-front analysis for selection of genes. This alleviates the bias induced by class intrinsic characteristics of dominating classes. The use of Pareto-front analysis is demonstrated on two filter criteria commonly used for gene selection: F-score and KW-score. A significant improvement in classification performance and reduction in redundancy among top-ranked genes were achieved in experiments with both synthetic and real-benchmark data sets.
INDEX TERMS
Gene expression, Bioinformatics, Computational biology, Redundancy, Cancer, Training, Benchmark testing,Pareto-front analysis, Aggregation statistics, filter methods, gene selection, multiobjective evolutionary optimization
CITATION
Jagath C. Rajapakse, Piyushkumar A. Mundra, "Multiclass Gene Selection Using Pareto-Fronts", IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 10, no. , pp. 87-97, Jan.-Feb. 2013, doi:10.1109/TCBB.2013.1
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