RENNSH: A Novel \alpha-Helix Identification Approach for Intermediate Resolution Electron Density Maps
Issue No. 01 - January/February (2012 vol. 9)
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/TCBB.2011.52
Lingyu Ma , Dept. of Comput. Sci., Univ. of Freiburg, Freiburg, Germany
M. Reisert , Dept. of Diagnostic Radiol., Univ. Hosp. Freiburg, Freiburg, Germany
H. Burkhardt , Dept. of Comput. Sci., Univ. of Freiburg, Freiburg, Germany
Accurate identification of protein secondary structures is beneficial to understand three-dimensional structures of biological macromolecules. In this paper, a novel refined classification framework is proposed, which treats alpha-helix identification as a machine learning problem by representing each voxel in the density map with its Spherical Harmonic Descriptors (SHD). An energy function is defined to provide statistical analysis of its identification performance, which can be applied to all the α-helix identification approaches. Comparing with other existing α-helix identification methods for intermediate resolution electron density maps, the experimental results demonstrate that our approach gives the best identification accuracy and is more robust to the noise.
Training, Proteins, Labeling, Principal component analysis, Harmonic analysis, Bioinformatics, Query processing
Lingyu Ma, M. Reisert and H. Burkhardt, "RENNSH: A Novel \alpha-Helix Identification Approach for Intermediate Resolution Electron Density Maps," in IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 9, no. 1, pp. 228-239, 2011.