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Issue No. 01 - January/February (2012 vol. 9)
ISSN: 1545-5963
pp: 228-239
Lingyu Ma , Dept. of Comput. Sci., Univ. of Freiburg, Freiburg, Germany
M. Reisert , Dept. of Diagnostic Radiol., Univ. Hosp. Freiburg, Freiburg, Germany
H. Burkhardt , Dept. of Comput. Sci., Univ. of Freiburg, Freiburg, Germany
ABSTRACT
Accurate identification of protein secondary structures is beneficial to understand three-dimensional structures of biological macromolecules. In this paper, a novel refined classification framework is proposed, which treats alpha-helix identification as a machine learning problem by representing each voxel in the density map with its Spherical Harmonic Descriptors (SHD). An energy function is defined to provide statistical analysis of its identification performance, which can be applied to all the α-helix identification approaches. Comparing with other existing α-helix identification methods for intermediate resolution electron density maps, the experimental results demonstrate that our approach gives the best identification accuracy and is more robust to the noise.
INDEX TERMS
Training, Proteins, Labeling, Principal component analysis, Harmonic analysis, Bioinformatics, Query processing,refined classification., Structural bioinformatics, secondary structure identification, intermediate resolution electron density maps, spherical harmonic descriptors
CITATION
Lingyu Ma, M. Reisert, H. Burkhardt, "RENNSH: A Novel \alpha-Helix Identification Approach for Intermediate Resolution Electron Density Maps", IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 9, no. , pp. 228-239, January/February 2012, doi:10.1109/TCBB.2011.52
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