Issue No. 06 - November/December (2011 vol. 8)
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/TCBB.2011.75
Yi Shang , University of Missouri, Columbia
Dong Xu , University of Missouri, Columbia
Qingguo Wang , University of Missouri, Columbia
In protein tertiary structure prediction, a crucial step is to select near-native structures from a large number of predicted structural models. Over the years, extensive research has been conducted for the protein structure selection problem with most approaches focusing on developing more accurate energy or scoring functions. Despite significant advances in this area, the discerning power of current approaches is still unsatisfactory. In this paper, we propose a novel consensus-based algorithm for the selection of predicted protein structures. Given a set of predicted models, our method first removes redundant structures to derive a subset of reference models. Then, a structure is ranked based on its average pairwise similarity to the reference models. Using the CASP8 data set containing a large collection of predicted models for 122 targets, we compared our method with the best CASP8 quality assessment (QA) servers, which are all consensus based, and showed that our QA scores correlate better with the GDT-TSs than those of the CASP8 QA servers. We also compared our method with the state-of-the-art scoring functions and showed its improved performance for near-native model selection. The GDT-TSs of the top models picked by our method are on average more than 8 percent better than the ones selected by the best performing scoring function.
Protein tertiary structure, protein structure selection, quality assessment, consensus approach, metapredictor, critical assessment of protein structure prediction.
Yi Shang, Dong Xu, Qingguo Wang, "Improving a Consensus Approach for Protein Structure Selection by Removing Redundancy", IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 8, no. , pp. 1708-1715, November/December 2011, doi:10.1109/TCBB.2011.75