Issue No. 06 - November/December (2011 vol. 8)
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/TCBB.2010.124
Tamir Tuller , Weizmann Institute of Science, Rehovot
Elchanan Mossel , Weizmann Institute of Science, Rehovot and University of California Berkeley, Berkeley
Markov models are extensively used in the analysis of molecular evolution. A recent line of research suggests that pairs of proteins with functional and physical interactions co-evolve with each other. Here, by analyzing hundreds of orthologous sets of three fungi and their co-evolutionary relations, we demonstrate that co-evolutionary assumption may violate the Markov assumption. Our results encourage developing alternative probabilistic models for the cases of extreme co-evolution.
Markov models, models of molecular evolution, co-evolution, phylogenetic reconstruction.
Tamir Tuller, Elchanan Mossel, "Co-evolution Is Incompatible with the Markov Assumption in Phylogenetics", IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 8, no. , pp. 1667-1670, November/December 2011, doi:10.1109/TCBB.2010.124