Issue No. 02 - March/April (2011 vol. 8)
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/TCBB.2010.93
Xiaotong Lin , The University of Kansas, Lawrence
Jong Cheol Jeong , University of Kansas, Lawrence
Xue-Wen Chen , The University of Kansas, Lawrence
While genome sequencing projects have generated tremendous amounts of protein sequence data for a vast number of genomes, substantial portions of most genomes are still unannotated. Despite the success of experimental methods for identifying protein functions, they are often lab intensive and time consuming. Thus, it is only practical to use in silico methods for the genome-wide functional annotations. In this paper, we propose new features extracted from protein sequence only and machine learning-based methods for computational function prediction. These features are derived from a position-specific scoring matrix, which has shown great potential in other bininformatics problems. We evaluate these features using four different classifiers and yeast protein data. Our experimental results show that features derived from the position-specific scoring matrix are appropriate for automatic function annotation.
Clustering, classification, and association rules, data mining, feature extraction or construction, mining methods and algorithms.
Xiaotong Lin, Jong Cheol Jeong, Xue-Wen Chen, "On Position-Specific Scoring Matrix for Protein Function Prediction", IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 8, no. , pp. 308-315, March/April 2011, doi:10.1109/TCBB.2010.93