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2017 IEEE Pacific Visualization Symposium (PacificVis) (2017)
Seoul, South Korea
April 18, 2017 to April 21, 2017
ISSN: 2165-8773
ISBN: 978-1-5090-5739-9
pp: 265-269
Tommy Dang , Department of Computer Science, Texas Tech University, United States of America
Paul Murray , Department of Computer Science, University of Illinois at Chicago, United States of America
Angus Forbes , Department of Computer Science, University of Illinois at Chicago, United States of America
Systems biologists and cancer researchers require interactive visualization tools that enable them to more easily navigate and discover patterns at different levels of the biological hierarchy of signaling pathways. Furthermore, biologists are often interested in understanding and exploring the causal biochemical links between processes. When exploring the literature of particular biological pathways or specific proteins within those pathways, biologists find it useful to know the contexts in which biochemical links are active and, importantly, to be aware of potential conflicts when different experiments introduce alternative interpretations of the function of a pathway or biochemical reaction. We introduce BioLinker, a interactive visualization system that helps users to perform bottom-up exploration of complex protein interaction networks. Five interconnected views provide the user with a range of ways to explore pathway data, including views that show potential conflicts within pathway databases and publications and that highlight contextual information about individual proteins. Additionally, we discuss system details to show how our system manages the large amount of protein interactions extracted from the literature of biological pathways.
Proteins, Indexes, Data visualization, Cancer, Genomics,Protein interaction network, Dynamic network visualization, Potential conflict matrix
Tommy Dang, Paul Murray, Angus Forbes, "BioLinker: Bottom-up exploration of protein interaction networks", 2017 IEEE Pacific Visualization Symposium (PacificVis), vol. 00, no. , pp. 265-269, 2017, doi:10.1109/PACIFICVIS.2017.8031603
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