International Conference on Nano/Micro Engineered and Molecular Systems (2009)
Jan. 5, 2009 to Jan. 8, 2009
Xian Huang , Mechanical Engineering Department, Columbia University, New York, USA
Siqi Li , Chemistry and Biochemistry Department, University of South Carolina, Columbia, USA
Jerome Schultz , Bioengineering Department, University of California, Riverside, USA
Qian Wang , Chemistry and Biochemistry Department, University of South Carolina, Columbia, USA
Qiao Lin , Mechanical Engineering Department, Columbia University, New York, USA
In this paper, we present two designs for developing a biocompatible affinity MEMS glucose sensor. Based on these designs, two devices were fabricated and characterized. These devices, consisting of a micro- cantilever or membrane situated inside microchambers, are driven by a remote magnetic field and separated from the sensing environment by a semi-permeable membrane. A change in viscosity induced by the binding of poly(acrylamide-ran-3-acrylamidophenylboronic acid) (PAA-ran-PAAPBA) copolymer with glucose is determined by the damped vibration of the cantilever or the membrane in the devices. The cantilever-based sensor has been used to measure physiologically relevant glucose concentrations from 0 to 324 mg/dL with a response time of approximately 3 minutes. This response time was further improved to 1.5 minutes using the membrane-based sensor.
X. Huang, Q. Lin, Q. Wang, J. Schultz and S. Li, "A biocompatible affinity MEMS sensor for continuous monitoring of glucose," International Conference on Nano/Micro Engineered and Molecular Systems(NEMS), Shenzhen, China, 2009, pp. 797-802.