2013 IEEE 3rd International Conference on Computational Advances in Bio and medical Sciences (ICCABS) (2011)
Orlando, FL, USA
Feb. 3, 2011 to Feb. 5, 2011
Anna Tan-Wilson , SUNY Binghamton Biological Sciences Department, USA
Patrick H Madden , SUNY Binghamton Computer Science Department, USA
Jason Gallia , SUNY Binghamton Computer Science Department, USA
In this paper we present a new de novo method to identify protein and peptide amino acid sequences from tandem mass spectrometry (MS/MS) data. Our approach uses an integer knapsack dynamic programming formulation, which allows for optimization to directly consider ions other than the typical b and y variety. Rather than acting as â€œnoise" which obscures the sequence in question, the additional ions can be used to improve identifications, and provide greater confidence in the results. We validate our approach using raw experimental data.
Anna Tan-Wilson, Patrick H Madden, Jason Gallia, "Poster: De novo protein identification by dynamic programming", 2013 IEEE 3rd International Conference on Computational Advances in Bio and medical Sciences (ICCABS), vol. 00, no. , pp. 242-243, 2011, doi:10.1109/ICCABS.2011.5729896