2008 IEEE Fourth International Conference on eScience (2008)
Dec. 7, 2008 to Dec. 12, 2008
A general method for coupling individual living cells to computers is presented. This method is called Visual-Servoing Optical Microscopy™ (VSOM™). Protocols, instrumentation, and software are described and experimental results are presented. During VSOM experiments, automated decisions are made as single cell responses to computer-applied stimuli are interpreted in real-time. Well-annotated live cell responses are stored in distributed VSOM databases in real-time. This closed-loop method enables automated extraction of knowledge from individual living cells.
cells, microscopy, fluorescence microscopy, biologic assays, computer vision systems, computer-assisted image interpretation, visual servoing, biomedical informatics
Daniel E. Callahan, "Coupling Computers to Living Cells for Automated Knowledge Extraction", 2008 IEEE Fourth International Conference on eScience, vol. 00, no. , pp. 446-447, 2008, doi:10.1109/eScience.2008.152