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2008 IEEE Fourth International Conference on eScience (2008)
Indianapolis, IN
Dec. 7, 2008 to Dec. 12, 2008
ISBN: 978-1-4244-3380-3
pp: 446-447
ABSTRACT
A general method for coupling individual living cells to computers is presented. This method is called Visual-Servoing Optical Microscopy™ (VSOM™). Protocols, instrumentation, and software are described and experimental results are presented. During VSOM experiments, automated decisions are made as single cell responses to computer-applied stimuli are interpreted in real-time. Well-annotated live cell responses are stored in distributed VSOM databases in real-time. This closed-loop method enables automated extraction of knowledge from individual living cells.
INDEX TERMS
cells, microscopy, fluorescence microscopy, biologic assays, computer vision systems, computer-assisted image interpretation, visual servoing, biomedical informatics
CITATION
Daniel E. Callahan, "Coupling Computers to Living Cells for Automated Knowledge Extraction", 2008 IEEE Fourth International Conference on eScience, vol. 00, no. , pp. 446-447, 2008, doi:10.1109/eScience.2008.152
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