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2008 IEEE Fourth International Conference on eScience (2008)
Indianapolis, IN
Dec. 7, 2008 to Dec. 12, 2008
ISBN: 978-1-4244-3380-3
pp: 446-447
ABSTRACT
A general method for coupling individual living cells to computers is presented. This method is called Visual-Servoing Optical Microscopy™ (VSOM™). Protocols, instrumentation, and software are described and experimental results are presented. During VSOM experiments, automated decisions are made as single cell responses to computer-applied stimuli are interpreted in real-time. Well-annotated live cell responses are stored in distributed VSOM databases in real-time. This closed-loop method enables automated extraction of knowledge from individual living cells.
INDEX TERMS
cells, microscopy, fluorescence microscopy, biologic assays, computer vision systems, computer-assisted image interpretation, visual servoing, biomedical informatics
CITATION

D. E. Callahan, "Coupling Computers to Living Cells for Automated Knowledge Extraction," 2008 IEEE Fourth International Conference on eScience(ESCIENCE), Indianapolis, IN, 2008, pp. 446-447.
doi:10.1109/eScience.2008.152
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