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The CancerGrid consortium is developing open-standards cancer informatics to address the challenges posed by modern cancer clinical trials. Their costly-to-build information systems are often composed of incompatible variants of the same modules, and record data in ways that prevent any meaningful result analysis across similar projects. The information technology required to enable this kind of large-scale, collaborative science will need to support easy and rapid development and deployment of reliable and flexible software systems that enable syntactic, semantic and computational interoperability. This paper presents a framework for the metamodel-based generation of Web Services Resource Framework (WSRF) compliant Service-Oriented Architecture (SOA) for collaborative cancer research. A generic SOA model is built based on a combination of the standard domain metamodel and metadata, and the WSRF standards. This model is then employed to automate the generation of the trial management systems used in cancer clinical trials. The integration of the WSRF standards with the standard domain metamodel enables the generated systems to support syntactic, semantic and computational interoperability that is essential for collaborative cancer research. Automating the model-driven system generation not only speeds up its development, but also enforces its conformance to these standards. The SOA model and generated system are currently being evaluated for use in early-phase clinical trials. Although primarily targeted at cancer research, our approach can be readily applied to other application scenarios and domains for which a similar metamodel and metadata are available. Moreover, the techniques used to generate WSRF Web services are directly applicable to other WSRF-based applications.

R. Calinescu et al., "Metamodel-Based Generation of WSRF-Compliant SOA for Collaborative Cancer Research," 2008 IEEE Fourth International Conference on eScience(ESCIENCE), Indianapolis, IN, 2008, pp. 406-407.
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