Electronic Design, Test and Applications, IEEE International Workshop on (2002)
Christchurch, New Zealand
Jan. 29, 2002 to Jan. 31, 2002
Paul Gaynor , University of Waikato
Jonathan Skipwith , University of Waikato
The bio-physical effect known as electroporation or electropermeabilization is becoming more widely used in medical treatments, especially for chemotherapy and gene therapy. Conventional electrical apparatus used for these treatments are based on DC voltage pulses which may not be optimal. Indications are that AC pulses may provide significant improvements. In order to experimentally investigate the advantages and disadvantages of AC pulses, appropriate electrical apparatus is required. Owing to unique electrical conditions, appropriate commercial apparatus is essentially unobtainable.A high voltage linear amplifier design incorporating vacuum tube valves is presented that could facilitate AC pulse experimentation. Valves are used as they most readily suit the desired electrical specifications of an output voltage of 4kVp, a bandwidth of 500Hz - 5MHz, a voltage gain of 52dB, and an output impedance of <100ohms.
electroporation, electropermeabilization, high voltage amplifier, valves, vacuum tubes, AC pulses
Paul Gaynor, Jonathan Skipwith, "A High Voltage Amplifier for use in Medical Applications of Electroporation", Electronic Design, Test and Applications, IEEE International Workshop on, vol. 00, no. , pp. 483, 2002, doi:10.1109/DELTA.2002.994679