Computer Science and Information Engineering, World Congress on (2009)
Los Angeles, California USA
Mar. 31, 2009 to Apr. 2, 2009
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/CSIE.2009.15
Gene-gene interaction analyses have been used to identify common disease susceptibility genes. Recently, evidence of a statistical interaction among several SNPs has been reported in Crohn's disease. This paper explores the application of Apriori-Gen algorithm on the association study in Crohn's disease. The Apriori-Gen algorithm has been applied to SNP data of Crohn's disease for association study. The result shows the interaction among 5 SNPs with support of 50% and confidence of 60%. The relative risk RR and odds ratio OR are 1.98 and 2.59, respectively. The experiment results indicate that the interaction among those SNPs is responsible for the disease.
Apriori-Gen algorithm, association study, relative risk, odds ratio
Weidong Mao, "The Application of Apriori-Gen Algorithm on the Interaction Analysis of SNPs in Genetic Disease", Computer Science and Information Engineering, World Congress on, vol. 03, no. , pp. 626-630, 2009, doi:10.1109/CSIE.2009.15