Computational Systems Bioinformatics Conference, International IEEE Computer Society (2002)

Stanford, California

Aug. 14, 2002 to Aug. 16, 2002

ISBN: 0-7695-1653-X

pp: 21

Alexandros P. Stamatakis , Technical University of Munich

Thomas Ludwig , Ruprecht-Karls-University

Harald Meier , Technical University of Munich

Marty J. Wolf , Bemidji State University

ABSTRACT

Heuristics for the NP-complete problem of calculating the optimal phylogenetic tree for a set of aligned rRNA sequences based on the maximum likelihood method are computationally expensive. In most existing algorithms the tree evaluation and branch length optimization functions, calculating the likelihood value for each tree topology examined in the search space, account for the greatest part of overall computation time. This paper introduces AxML, a program derived from fastDNAml, incorporating a fast topology evaluation function. The algorithmic optimizations introduced, represent a general approach for accelerating this function and are applicable to both sequential and parallel phylogeny programs, irrespective of their search space strategy. Therefore, their integration into three existing phylogeny programs rendered encouraging results. Experimental results on conventional processor architectures show a global run time improvement of 35% up to 47% for the various test sets and program versions we used.

INDEX TERMS

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CITATION

M. J. Wolf, H. Meier, A. P. Stamatakis and T. Ludwig, "AxML: A Fast Program for Sequential and Parallel Phylogenetic Tree Calculations Based on the Maximum Likelihood Method,"

*Computational Systems Bioinformatics Conference, International IEEE Computer Society(CSB)*, Stanford, California, 2002, pp. 21.

doi:10.1109/CSB.2002.1039325

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