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2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) (2014)
Belfast, United Kingdom
Nov. 2, 2014 to Nov. 5, 2014
ISBN: 978-1-4799-5669-2
pp: 160-161
Shanshan Shen , Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China
Yaoxian Wang , Dongzhimen Hospital Eastern Affiliated to Beijing University of Chinese Medicine, Beijing, 101121, China
Guang Zheng , School of Information Science and Engineering Technology Lanzhou University, Lanzhou, 730000, China
Xiaojuan He , Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China
Yong Tan , Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China
Ke Zhou , Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China
Dongmei Jia , Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China
Aiping Lu , Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China
Miao Jiang , Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China
ABSTRACT
Tinnitus is the most common medical symptom that can be debilitating. Chinese herbal medicines (CHMs) play important roles in tinnitus treatment. This study analyzed the most frequently prescribed herbs used to treat tinnitus and the molecular mechanisms of therapeutic effects of these CHMs by text mining and bioinformatics technique. Results showed that pinellia ternate (Banxia) and gastrodin (Tianma) are the most frequently prescribed CHMs for treatment tinnitus. The molecular mechanisms of therapeutic effects of two CHMs were focused on sertoli cell-sertoli cell juntion signaling and NRF2-mediated oxidative stress response signaling. Integrative text mining and bioinformatics analysis may be a promising approach to find new drug and decipher their molecular mechanism intuitively.
INDEX TERMS
Proteins, Bioinformatics, Databases, Text mining, Educational institutions, Stress, Image color analysis
CITATION

S. Shen et al., "Applying bioinformatic technique to discovery molecular mechansim of Banxia and Tianma combination treating tinnitus," 2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Belfast, United Kingdom, 2014, pp. 160-161.
doi:10.1109/BIBM.2014.6999348
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