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2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) (2014)
Belfast, United Kingdom
Nov. 2, 2014 to Nov. 5, 2014
ISBN: 978-1-4799-5669-2
pp: 476-479
Guang Zheng , School of Information Science-Engineering, Lanzhou University, Lanzhou, 730000, China
Tong Wei , School of Information Science-Engineering, Lanzhou University, Lanzhou, 730000, China
Changsheng Ma , School of Information Science-Engineering, Lanzhou University, Lanzhou, 730000, China
Jianjun Liu , School of Information Science-Engineering, Lanzhou University, Lanzhou, 730000, China
Jinyu Liu , School of Information Science-Engineering, Lanzhou University, Lanzhou, 730000, China
Cheng Lu , Institute for Advancing Translational Medicine in Bone & Joint Diseases, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong
Aiping Lu , Institute for Advancing Translational Medicine in Bone & Joint Diseases, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong
ABSTRACT
Duhuo-Jisheng-Tang is a Chinese herbal formula designed to treat rheumatoid arthritis (RA) with syndrome dual deficiency of liver and kidney. Although its therapeutic clinical effect is widely accepted over one thousand years, its therapeutic agents are still obscure. In this study, we explored the potential therapeutic agents of Duhuo-Jisheng-Tang for RA by integrating leading knowledge databases of different biomedical domains. The molecule mechanism includes compositional herbal medicine, chemical compound, target protein, RA OMIM genes, FDA approved RA drug targets, and pathways. As a result, Duhuo-Jisheng-Tang's 11 target proteins can be found in RA's OMIM genes (e.g., UGT1, UGT1A9, GNT1, and JAK3) and FDA approved RA drug targets (e.g., CMKBR2/5, CCR2/5, APRF, and STAT1/3). What's more, these 11 genes/proteins are mainly enriched in pathways of disease, immune system, signal transduction, and metabolism. It demonstrates that Duhuo-Jisheng-Tang may regulate a wide range of different systems associated with RA which might indicate that Chinese herbal formula's therapeutic effects are demonstrated through system-level regulation rather than targeting disease specified genes/proteins.
INDEX TERMS
Proteins, Chemical compounds, Databases, Protein engineering, Arthritis, Diseases, Drugs
CITATION

G. Zheng et al., "Exploring potential therapeutic agents of Duhuo-Jisheng-Tang for rheumatoid arthritis," 2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Belfast, United Kingdom, 2014, pp. 476-479.
doi:10.1109/BIBM.2014.6999203
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