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2016 IEEE 16th International Conference on Bioinformatics and Bioengineering (BIBE) (2016)
Taichung, Taiwan
Oct. 31, 2016 to Nov. 2, 2016
ISBN: 978-1-5090-3834-3
pp: 71-78
ABSTRACT
Wilms tumor is one of lethal child renal cancers, for which no known disease causing mechanisms exist. In this paper, we tried to identify possible disease causing microRNA(miRNA)-mRNA pairs (interactions) by analyzing (partially matched) miRNA/mRNA gene expression profiles with the recently proposed principal component analysis based unsupervised feature extraction. It successfully identified multiple miRNA-mRNA pairs whose biological natures are convincing. Correlation coefficients between miRNA and mRNA expression in matched parts of profiles turned out to be significantly negative. Constructed miRNA-mRNA network will be a key to understand Wilms tumor causing mechanisms.
INDEX TERMS
Tumors, Kidney, Principal component analysis, Correlation, Iron, Loading
CITATION

Y. Taguchi, "microRNA-mRNA Interaction Identification in Wilms Tumor Using Principal Component Analysis Based Unsupervised Feature Extraction," 2016 IEEE 16th International Conference on Bioinformatics and Bioengineering (BIBE), Taichung, Taiwan, 2016, pp. 71-78.
doi:10.1109/BIBE.2016.14
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