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2013 IEEE 13th International Conference on Bioinformatics and Bioengineering (BIBE) (2013)
Chania, Greece
Nov. 10, 2013 to Nov. 13, 2013
ISBN: 978-1-4799-3163-7
pp: 1-4
M. Spanakis , Institute of Computer Science Foundation of Research and Technology-Hellas (FORTH) GR-71110 Heraklion, Crete, Greece
E. Papadaki , Department of Medical Imaging, University Hospital of Heraklion, GR-71110, Crete, Greece
D. Kafetzopoulos , Institute of Molecular Biology and Biotechnology, Foundation for Research & Technology-Hellas (FORTH) GR-71110 Heraklion, Crete, Greece
A. Karantanas , Radiology-University of Crete, Chair-Department of Medical Imaging, University Hospital of Heraklion, GR-71110, Crete, Greece
T. G. Maris , Department of Medical Imaging, University Hospital of Heraklion, GR-71110, Crete, Greece
V. Sakkalis , Institute of Computer Science Foundation of Research and Technology-Hellas (FORTH) GR-71110 Heraklion, Crete, Greece
K. Marias , Institute of Computer Science Foundation of Research and Technology-Hellas (FORTH) GR-71110 Heraklion, Crete, Greece
ABSTRACT
The generation of “virtual twins” of patients (Avatars) through integration of multiscale data gained from both the clinical profile of the patient and — omics tools, could create an appropriate environment for stratification of patients in fitting cohorts of “virtual populations”. Physiologically based pharmacokinetic & pharmacodynamic (PB/PK/PD) models as in silico clinical trial tools can estimate the PK/PD profiles in specific populations. In this work we discuss examples of how patient Avatars could be exploited in the context of in silico clinical trials and help in identifying novel biomarkers for personalized diagnosis. The PB/PK/PD models, neuroimaging and — omics data, may be fused together to further advance current decision making processes in clinical practice.
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CITATION

M. Spanakis et al., "Exploitation of patient avatars towards stratified medicine through the development of in silico clinical trials approaches," 13th IEEE International Conference on BioInformatics and BioEngineering(BIBE), Chania, Greece Greece, 2014, pp. 1-4.
doi:10.1109/BIBE.2013.6701554
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