Issue No. 01 - January-February (2007 vol. 24)
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/MDT.2007.25
S. Krishnamoorthy , Baxter Healthcare
J.J. Feng , Procter & Gamble
Z.J. Chen , CFD Research
Lab-on-a-chip systems have a variety of applications in biotechnology, such as biochemical analysis and high-throughput screening. Separation of micron-sized particles and cells is critical in many of these applications. Field flow fractionation (FFF) using dielectrophoresis (DEP) is fast-becoming an established methodology for sorting and manipulating particles and cells. However, design and development of FFF systems poses many challenges because DEP forces vary significantly with applied electric potential and frequency, as well as dielectric properties of the particles and cells and the medium. This article illustrates simulation-based analysis of FFF devices that employ both conventional and traveling-wave forms of DEP forces, in conjunction with laminar flows. High-fidelity simulations provide deeper insight into various competing forces, and facilitate the selection of optimal geometry and process parameters for maximum performance.
dielectrophoresis, field flow fractionation, microfluidics, lab on a chip, bioassays, particles, cells
S. Krishnamoorthy, J.J. Feng, Z.J. Chen, "Simulation-Based Analysis of Dielectrophoretic Field Flow Fractionation Devices", IEEE Design & Test of Computers, vol. 24, no. , pp. 50-58, January-February 2007, doi:10.1109/MDT.2007.25