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Finding the genetic causes of disease is a challenging problem for biologists and mathematicians alike. This article describes the difficulties of the problems, two general algorithmic approaches to solving it, and areas of current research where the problem has not yet been adequately solved
Mark J. Daly, "The Computational Challenge of Linkage Analysis: What Causes Diseases?", Computing in Science & Engineering, vol. 1, no. , pp. 18-25, May/June 1999, doi:10.1109/5992.764212
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