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Over the past 10 to 15 years, numerous technical innovations have revolutionized molecular biology. These include the development of high-throughput DNA amplification techniques, improved DNA sequencing methods, more efficient procedures for determining protein structures, and new technologies for monitoring cellular processes at a global level. These breakthroughs have led to an explosion in the variety and quantity of data routinely generated in molecular biology research.

D. K. Slonim and J. P. Mesirov, "Guest Editors' Introduction: Computational Biology," in Computing in Science & Engineering, vol. 1, no. , pp. 16-17, 1999.
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