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Issue No. 05 - May (2004 vol. 37)
ISSN: 0018-9162
pp: 26-33
James Hetherington , University College London
Ofer Margoninski , University College London
Peter Saffrey , University College London
Linzhong Li , University College London
Anne Warner , University College London
Rob Seymour , University College London
Anthony Finkelstein , University College London
By posing novel computational challenges and stretching the state of the art, bioinformatics has become the computing response to the molecular revolution in biology. But bioinformatics is only the first step in reshaping the life sciences. For further progress, we must return to the study of whole biological systems: the heart, cardiovascular system, brain, and liver.<p>Progress in systems biology will require computer scientists to work closely with life scientists and mathematicians. In contrast to the molecular biology revolution, computer science will actively engage in shaping systems biology. The prize to be attained is immense, ranging from in silico drug design and testing to individualized medicine that takes into account physiology and genetic profiles.</p>
James Hetherington, Ofer Margoninski, Peter Saffrey, Linzhong Li, Anne Warner, Rob Seymour, Anthony Finkelstein, "Computational Challenges of Systems Biology", Computer, vol. 37, no. , pp. 26-33, May 2004, doi:10.1109/MC.2004.1297236
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