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<p>The basic concept of interconnection-free biomolecular computing and its realization in a computing model based on the massive, natural parallelism between enzymes and their substrates are described. An approach to implementing the model is presented. The approach involves two primitive switching functions: detecting specific substrates in solution using enzyme-based biosensors and producing specific substrates in response to the electric signal from the biodevice's selection function. The major challenges involved in implementing the computational model are reviewed.</p>
Tatsuo Higuchi, Takafumi Aoki, Michitaka Kameyama, "Interconnection-Free Biomolecular Computing", Computer, vol. 25, no. , pp. 41-50, November 1992, doi:10.1109/2.166410
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