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<p>The basic concept of interconnection-free biomolecular computing and its realization in a computing model based on the massive, natural parallelism between enzymes and their substrates are described. An approach to implementing the model is presented. The approach involves two primitive switching functions: detecting specific substrates in solution using enzyme-based biosensors and producing specific substrates in response to the electric signal from the biodevice's selection function. The major challenges involved in implementing the computational model are reviewed.</p>

T. Higuchi, T. Aoki and M. Kameyama, "Interconnection-Free Biomolecular Computing," in Computer, vol. 25, no. , pp. 41-50, 1992.
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