An Integer Programming Formulation of the Parsimonious Loss of Heterozygosity Problem
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
By Bjarni V. Halldorsson, Daniele Catanzaro, Martine Labbe
Issue Date:November 2013
A loss of heterozygosity (LOH) event occurs when, by the laws of Mendelian inheritance, an individual should be heterozygote at a given site but, due to a deletion polymorphism, is not. Deletions play an important role in human disease and their detection ...