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Large-Scale Signaling Network Reconstruction
Found in: IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
By Eyup Serdar Ayaz, Seyedsasan Hashemikhabir, Tamer Kahveci, Tolga Can, Yusuf Kavurucu
Issue Date:November 2012
pp. 1696-1708
Reconstructing the topology of a signaling network by means of RNA interference (RNAi) technology is an underdetermined problem especially when a single gene in the network is knocked down or observed. In addition, the exponential search space limits the e...