Large-Scale Signaling Network Reconstruction
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
By Eyup Serdar Ayaz, Seyedsasan Hashemikhabir, Tamer Kahveci, Tolga Can, Yusuf Kavurucu
Issue Date:November 2012
Reconstructing the topology of a signaling network by means of RNA interference (RNAi) technology is an underdetermined problem especially when a single gene in the network is knocked down or observed. In addition, the exponential search space limits the e...