Entries with tag computational biology.

Modeling Helps Understand Human Immune System

Virginia Polytechnic Institute and State University researchers have created a computer model that helps scientists better understand the human immune system. They specifically looked at macrophage-cell responses. These cells typically identify and respond to pathogens that cause infection. However, a lengthy immune response can cause inflammatory diseases, such as multiple sclerosis or type 2 diabetes. To understand this phenomenon, the Virginia Tech scientists say, they studied how sequential pathogen attacks alter or reprogram macrophage immune responses. The scientists utilized the Metropolis algorithm—a statistical approach commonly used in physics and chemistry—in their model to determine the molecular mechanisms involved in such activities. The researchers, who published their work in PLoS Computational Biology, say more studies and testing are needed. (PhysOrg)(Virginia Tech)(PLoS Computational Biology)

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