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2008 Eighth International Conference on Hybrid Intelligent Systems
The Impact of Local Search on Protein-Ligand Docking Optimization
September 10-September 12
ISBN: 978-0-7695-3326-1
ASCII Text
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Jorge Tavares, Alexandru-Adrian Tantar, Nouredine Melab, El-Ghazali Talbi, "The Impact of Local Search on Protein-Ligand Docking Optimization," Hybrid Intelligent Systems, International Conference on, pp. 53-58, 2008 Eighth International Conference on Hybrid Intelligent Systems, 2008.
 
 
BibTex
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@article{ 10.1109/HIS.2008.14,
author = {Jorge Tavares and Alexandru-Adrian Tantar and Nouredine Melab and El-Ghazali Talbi},
title = {The Impact of Local Search on Protein-Ligand Docking Optimization},
journal ={Hybrid Intelligent Systems, International Conference on},
volume = {0},
year = {2008},
isbn = {978-0-7695-3326-1},
pages = {53-58},
doi = {http://doi.ieeecomputersociety.org/10.1109/HIS.2008.14},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
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TY - CONF
JO - Hybrid Intelligent Systems, International Conference on
TI - The Impact of Local Search on Protein-Ligand Docking Optimization
SN - 978-0-7695-3326-1
SP53
EP58
A1 - Jorge Tavares,
A1 - Alexandru-Adrian Tantar,
A1 - Nouredine Melab,
A1 - El-Ghazali Talbi,
PY - 2008
KW - Locality analysis
KW - local search
KW - mutation
KW - molecular docking
VL - 0
JA - Hybrid Intelligent Systems, International Conference on
ER -
 
Common evolutionary approaches to protein-ligand docking optimization use mutation operators based on Gaussian and Cauchy distributions, with local search hybrids. The choice of a local search method is important for an efficient algorithm. We investigate the impact of local search with mutation operators by performing a locality analysis. High locality means that small variations in the genotype imply small variations in the phenotype. Results show that local search hybrids reduce locality and act as local optimizers with the solution as a starting point.
Index Terms:
Locality analysis, local search, mutation, molecular docking
Citation:
Jorge Tavares, Alexandru-Adrian Tantar, Nouredine Melab, El-Ghazali Talbi, "The Impact of Local Search on Protein-Ligand Docking Optimization," his, pp.53-58, 2008 Eighth International Conference on Hybrid Intelligent Systems, 2008
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