..In this paper, we propose the development strategy of message transaction system in electronic business to business system with consideration of security. B2B must be designed to transfer electronic data between business and business in completely secured and reliable form. For the purpose of secured and reliable transaction of electronic data, we propose the complete framework . Also, we provide message system for communication and transaction for E-business, and provide message test set through the development strategy for interoperability of message. The message test set is a data class modeling of ebXML MSH(message service handler) which supports message test set to ebXML message transaction of e-business. Finally, we implemented the message processing system through SMTP Mail transaction into ebMSH for the ebXML Message Test-Set for message service transaction after database relationship.