In recent years, there has been a frequent occurrence of virus-related incidents, including cases where a virus infection has caused the unauthorized release of confidential information. Viruses should be considered a society-level security risk. However, the mainstream approach to addressing a virus is basically to implement countermeasures for the virus after the damage has occurred. Some of these countermeasures are unable to keep up with the current pace at which viruses are occurring. To address this problem, in this research, we developed a system to generate unknown virus extermination software automatically, without any manual operations. The developed system is designed to automatically generate software that detects and exterminates an unknown virus, by using both a dynamic heuristic that uses a virtual PC and a technique to automatically generate a signature from header data in the virus executable. We were able to verify the effectiveness of this system when we conducted experiments to check whether or not an actual virus could be exterminated by a vaccine that was automatically created for the virus with the developed system.