This paper describes xENoC, an automatic and component re-use HW-SW environment to build simulatable and synthesizable Network-on-Chip-based MPSoC architectures. xENoC is based on a tool, named NoCWizard, which uses an eXtensible Markup Language (XML) specification, and a set of modularized components and templates to generate many types of NoC instances by using Verilog HDL. This NoC models can be customized in terms of topology, tile location/mapping, RNIs generation, different types of routers, FIFO and packet/flit sizes, by simply modifying the XML specifications. Furthermore, xENoC is also composed of software components, i.e. RNI drivers and a parallel programming model, embedded Message Passing Interface (eMPI), which let us to carry out a complete HW-SW co-design methodology to design distributed-memory NoC-based MPSoCs parallel applications. Through xENoC different distributed-memory NoC-based MPSoCs designs have been created simulated and prototyped in physical platforms (e.g. FPGA boards), and some parallel multiprocessor test traffic applications are running there as system level demonstrators.