Distributed simulation technology was originally developed for application in the military domain. Subsequently, the availability of synchronisation middleware such as the Runtime Infrastructure of the High Level Architecture has also inspired research looking at application of distributed simulation for modelling and analysis of other large-scale, heterogeneous systems such as supply networks. In this keynote talk, research accomplishments that have been made in Singapore in the area of distributed simulation in the context of manufacturing and logistics will be reviewed. With a dozen wafer fabrication plants and more than 20 assembly & test facilities currently being operated in Singapore, potential application scenarios have naturally been looking at the semiconductor manufacturing domain. Challenges in view of implementation of distributed simulation in an industrial environment and application for the resolution of real-world problems will be discussed as well.