In today’s business, the importance of understanding consumer behavior has never been more important to supply chain members. Retailers are on the key node of supply chain to transfer consumer’s requirement, so retailers’ satisfaction can reflect the efficiency of the supply chain operation. In this paper, a class of model and computational intelligence in supply chain network design considering retailer satisfaction is studied. The problem is divided into two sections, the first one is to evaluate the validity of candidate retailers and the work of filtering inefficient retailers is finished. The second one is to choose different parameters to reflect the satisfaction of retailers. Through these two steps, an efficient network is formed.