Global interconnection and communication at high clock frequencies are becoming more problematic in FPGA. In this paper, we address this problem by presenting an interconnect wave-pipelining strategy, which utilizes the existing programmable interconnects fabrics to provide high-throughput communication in FPGA. Two design approaches for interconnect wave-pipelining, using simple clock phase shifting and asynchronous phase encoding, are presented in this paper. Experimental results from a Xilinx Virtex-5 FPGA device are also presented.