Current VLSI designs face a serious performance bottleneck due to reverse scaling of global interconnects as CMOS technology scales into VDSM regime. Interconnections techniques which decrease delay, power, and ensure signal integrity, play an important role in the growth of semiconductor industry into future generations. In this paper we present a novel hybrid insertion methodology for on-chip global interconnects. It takes advantage of repeaters and low-swing differential-signaling transceivers on driving long wires in different length, and optimally inserts them along the wires in order to decrease delay, power and gate area cost of interconnects. Simulation results using HSPICE for 0.18?m process showed that delay, power, delay-energy-product (EDP) and gate area cost were considerably decreased compared with other approaches available. Moreover, its computational technique is relatively easy and not limited to a specific low-swing differential-signaling transceiver. Therefore the methodology is very suitable for integration in EDA tool flow and beneficial for the reuse of low-swing differential-signaling transceivers.