Abstract: The identification of Tumor Cell of Bone Marrow Involvement (TCoBMI) is very difficult for the complexity of hematopoiesis in bone marrow. Based on the demand of medical application, in this paper, the multi-information fusion method based on the Modified Dempster-Shafer (MDS) and the research of the identification of TCoBMI is presented with three information sources of the micrograph of bone marrow, blood checks and clinical data. The experiment indicates that this method simulates the identification process of the experienced pathologist successfully. The identification of TCoBMI based on MDS Multi-information fusion method is feasible in medical application. The result suggests that the accuracy of identification is high and the method of three information sources fusing is a powerful aid of diagnosis to identify TCoBMI.