This paper presents a novel BIST (Built-In Self Test) scheme with scan chain segmentation. In the scheme, a combination of pseudo random patterns and single-weight patterns have been applied to CUT (Circuit Under Test). Scan chain is partitioned into multiple segments delimited by inverters. When a single weighted pattern is applied to a segmented scan chain, successive segments receive bit patterns with complementary weights. Several segment configurations may be required to achieve full fault coverage. In this scheme the control logic is inside the scan path and built-in self test can be implemented without compromising timing performance of CUT. Experiments show that our scheme can obtain very good fault coverage. Hardware implementation is simple and straightforward.