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9th International Symposium on Quality Electronic Design (isqed 2008)
High Resolution Read-Out Circuit for DNA Label-Free Detection System
March 17-March 19
ISBN: 978-0-7695-3117-5
This paper presents novel read-out electronic systems for a fast DNA label-less detection. The capacitive shift due to the hybridization effect is monitored by means of a charge sensitive amplifier and a differential stage. The systems provide an A/D conversion and an evaluation of the capacitive shift amount with a resolution of 11 bit. The read-out solutions demonstrate the ability to identify a 0.01% variation on the capacitive value of the sensor. The investigated techniques are suitable for monolithic systems or for a micro-fabricated array of sensors.
Index Terms:
DNA biosensor read-out. Charge sensitive front-end, differential read-out system.
Citation:
Daniela De Venuto, Bruno Ricc?, "High Resolution Read-Out Circuit for DNA Label-Free Detection System," isqed, pp.708-711, 9th International Symposium on Quality Electronic Design (isqed 2008), 2008
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