This talk focuses on the challenges and opportunities of extending Moore's Law from a radiation-induced soft error rate (SER) point of view. Driven primarily by power constraints and the economic need to scale, tomorrow's microprocessors will continue to integrate more cores and memory onto a roughly constant die area and to a lesser extend increase the clock frequency by implementing deeper pipelines and pushing the process. It is widely believed that this strategy -despite all challenges- will enable the semiconductor industry to extend Moore's Law for the next 1-2 decades.