This paper presents a simulation modeling way which used by software AMESim and MATLAB/ Simulink. The aim is to improve vehicle ride comfort and handling stability through integrated control vehicle chassis system. Then co-simulation model for vehicle semi-active suspension (SAS) and electric power steering (EPS) is present. AMESim is applied to build mechanical dynamics model for SAS and EPS. MATLAB/Simulink is used to build the integrated controller model of vehicle chassis system. Through build s-function to connect interface of AMESim and Simulink. Co-simulation results prove that in the case of integrated control, handling stability and ride comfort is better than solo SAS control or solo EPS control. In a word, the simulation model is proved to be valid, and it is helpful to provide a new method to research vehicle chassis dynamics simulation.