Biological processes, and in particular DNA hybridization, offer the potential to form the basis for the assembly of devices at micro- and nano-scales. Our aim is to imitate nature to self-assemble micro-scale parts (<100 microns) using DNA hybridization attachment process. In this paper, a new mechanical DNA hybridization modelling scheme is proposed in order to determine the feasibility of such processes. We expose here how and why DNA hybridization process can provide a good bound to self assemble components, and how molecular modelling methods allow to understand the physical mechanism of this process. Furthermore, the strength of DNA hybridization can be measured and optimised to corroborate and validate the modelling state using an experimental technology based on atomic force microscopy.