A 4-D B-spline model has been created to accurately capture the dynamic motion of the heart from tagged magnetic resonance imaging (MRI) enabling displacement field reconstruction of myocardial deformation. The 4-D model is allowed to deform based on the location of the tag lines for all frames within the constraints of the model?s spatio-temporal internal energy. From a displacement field, the corresponding long and short axis Lagrangian strain maps are produced. Motion fields from simulated data produced by a cardiac motion simulator are used to create corresponding strain images. In addition, strain images produced from porcine data with posterolateral myocardial in-farction are illustrated.