This paper addresses the issue of feasible business models for seamless multimedia content distribution and delivery over mobile, wireless and fixed networks. An open, interlayer approach to Content Delivery Networks sets the scene for a great deal of flexibility in the value network for content distribution and delivery by uncoupling CDN-related roles currently bound together in proprietary solutions. Based on empirical research among the most important CDN stakeholders (network operators, service providers, and content providers), this paper presents a set of business model scenarios for next-generation multimedia CDNs. It concludes that these CDNs will either be integrated downstream by network operators or ISPs or result in a new breed of service platform provider.