This paper describes a novel multi-resolution image segmentation algorithm for separating sharply focused objects-of-interest from other foreground or background objects in low depth of field (DOF) images, such as sports, telephoto, macro, and microscopic images.The algorithm takes a multi-scale context-dependent approach to segment images based on features extracted from wavelet coefficients in high frequency bands. The algorithm is fully automatic in that all parameters are image independent. Experiments with the algorithm on more than 100 low DOF images have shown results close to the human segmentation of these images. Besides high accuracy, the algorithm also provides high speed. A 768?512 pixel image can be segmented within two seconds on a Pentium Pro 300MHz PC.