This paper describes a model-driven methodology to provide a systematic means of programming RFID applications and managing a distributed RFID infrastructure. The centerpiece of the approach is a model that captures the device infrastructure, business operation structure, and their relationship. Building on the model, a management system can be designed to support various management tasks effectively, such as the enrollment, provisioning, and monitoring of devices. Similarly an application framework can be created for solution developers to create distributed RFID applications. Applications can be written against a business operation model and deployed on an evolving device infrastructure. A prototype shows that the approach facilitates the management and programming of an RFID infrastructure.