Histopathology, one of the most important routines of all laboratory procedures used in pathology, is critical for the diagnosis of cancer. Experienced pathologists read the histological slides acquired from biopsy specimen in order to outline malignant areas. Recently, in terms of histological image analysis the improvements in imaging techniques led to the discovery of virtual histological slides In this technique, a special microscope scans a glass slide and generates a virtual slide at a resolution of 0.25 ?m/pixel. Output images are of sufficiently high quality to generate immense interest within the research community. Since the recognition of cancer areas are time consuming and error prone, in this paper we describe a new method for automatic squamous cell carcinoma, known as head-neck cancer, detection using very large digital histological slides. The density-based clustering algorithm (DBSCAN) plays a key role in the determination of the corrupted cell nuclei. Using the Support Vector Machine (SVM) Classifier, the experimental results on seven head-neck slides show that the proposed algorithm performed well, obtaining an average of 96% accuracy. The classifier performance is evaluated using the standard precision and recall measures, as well as predictive accuracy.