This paper proposes a minimally supervised method for acquiring high-level semantic relations such as causality and prevention from the Web. Our method learns linguistic patterns that express causality such as “x gave rise to y”, and uses them to extract causal noun pairs like (global warming, malaria epidemic) from sentences like “global warming gave rise to a new malaria epidemic”. The novelty of our method lies in the use of semantic word classes acquired by large scale clustering for learning class dependent patterns. We demonstrate the effectiveness of this class based approach on three large-scale relation mining tasks from 50 million Japanese Web pages. In two of these tasks we obtained more than 30,000 relation instances with over 80% precision, outperforming a state-of-the-art system by a large margin.